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Some studies have shown that Bivalirudin seemed to be more efficacious and safer than unfractionated heparin(UFH) for patients undergoing ECMO and a significant reduction in the transfusion requirements of composite blood products in pediatric patients on ECMO (79, 80)

The peptide's safety profile has been established through extensive animal studies and human clinical trials, with minimal side effects reported even during long-term administration protocols extending multiple years